In-Vitro disintegration and dissolution of facile synthesised vegetable capsule films from Abelmoscus esculentus and Gracilaria corticata polysaccharides

• Published in: Progress in organic coatings 2021-06, Vol.155, p.106012, Article 106012
• Main Authors: Archana, G., Mani, Vimalraj, Nguyen, D. Duc, Ravindran, B., Rembulan, Glisina Dwinoor, La, D. Duc, Woong Chang, S., Nguyen, X. Hoan
• Format: Article
• Language: English
• Subjects: Abelmoscus esculentus; Disintegration; Dissolution; Elongation; Gelatin; Gracilaria corticata; In vitro disintegration; In vitro dissolution; Mechanical properties; Metallizing; Polyethylene terephthalate; Polysaccharide; Polysaccharides; Silicon dioxide; Tensile strength; Vegetables
• ISSN: 0300-9440; 1873-331X
• DOI: 10.1016/j.porgcoat.2020.106012

[Display omitted] •Vegetable capsule films were prepared with improved natural polymers.•Low-cost vegetable capsules with materials originating from plants were designed.•Better disintegration and faster dissolution were observed.•Inexpensive raw materials for sustained drug delivery systems were discovered. The physicochemical properties, in vitro disintegration, and dissolution times of empty vegetable capsule films prepared by the solvent casting method were compared with gelatin films. The morphological properties of the films, such as surface pH (6.2 ± 0.04–6.4 ± 0.05), appearance, OTR (Oxygen Transmission Rate), and thickness (within 70 mm) were also evaluated. The mechanical properties of the capsule films were determined. The Abelmoscus esculentus and Gracilaria corticata polysaccharide films blended at a ratio of 0.5/0.5 showed the highest tensile strength (TS) of 6.8 MPa and the optimum elongation of 23 %, which was higher than that of the gelatin (control) film (p ≤ 0.05). Barrier properties such as the oxygen permeation rate, particularly the A. esculentus film, could be tailored to meet specific requirements by coating the films with metallized PET, metallized CPP, EVOH, and AlO2, or SiO2.