A Case of Epithelial-Myoepithelial Carcinoma in the Nasal Cavity Treated with Definitive Chemoradiotherapy

• Published in: Türk onkoloji dergisi 2019, Vol.34 (1)
• Main Authors: Beyza Şirin Özdemi̇r, Aksu, Melek Gamze, Alper Tunga Deri̇n, Toru, Havva Serap, Kamil Karaali̇, Genç, Mine
• Format: Article
• Language: English
• Subjects: Cancer; Case reports; Chemotherapy; Cytokeratin; Drug dosages; Exocrine glands; Lymphatic system; Magnetic resonance imaging; Medical diagnosis; Medical prognosis; Medicine; Metastasis; Otolaryngology; Patients; Radiation; Radiation therapy; Sinuses; Surgery; Tumors; University faculty
• ISSN: 1300-7467; 2717-8978
• DOI: 10.5505/tjo.2019.1818

Epithelial-myoepithelial carcinoma (EMC) is an uncommon neoplasm that is predominantly seen in major salivary glands. Although it is considered as low grade, the high recurrence rate is quite common. EMC of the nasal cavity is extremely rare. A case of EMC detected in the nasal cavity is reported. A 44-year-old woman presented with a 1-year history of nasal congestion and bleeding. Magnetic resonance imaging (MRI) revealed a 4×4 cm necrotic expansile lesion involving the bilateral nasal cavity, extending to the nasopharynx, oral cavity, maxillary sinus, and ethmoid cells. The patient was found to be inoperable since complete surgical resection was not possible, and excisional biopsy was performed. Histopathological and immunohistochemical analyses led to a diagnosis of EMC. Definitive radiotherapy (RT) with concomitant cisplatin was applied. After 4 years, the patient is asymptomatic, and MRI showed a stable status with no progression. EMC is rarely seen in the nasal cavity. If possible, the first treatment modality should be surgery. The role of RT is controversial. To the best of our knowledge, this is the only case treated with definitive chemoradiotherapy for EMC in the nasal cavity.