Polysaccharide films modified by compounds of natural origin and silver having potential medical applications

In the first stage, seven polysaccharide films were prepared with varying compositions of starch, carboxymethyl starch (CMS), and carboxymethyl cellulose (CMC), together with glycerol and citric acid. From these samples, the most suitable film for possible future applications in medicine in the form...

Full description

Saved in:
Bibliographic Details
Published in:Cellulose (London) 2021-07, Vol.28 (11), p.7257-7271
Main Authors: Antosik, Adrian Krzysztof, Miądlicki, Piotr, Wilpiszewska, Katarzyna, Markowska-Szczupak, Agata, Koren, Zvi C., Wróblewska, Agnieszka
Format: Article
Language:English
Subjects:
Additives
Antiinfectives and antibacterials
Antimicrobial agents
Bioorganic Chemistry
Carboxymethyl cellulose
Ceramics
Chemistry
Chemistry and Materials Science
Citric acid
Composites
Glass
Glycerol
Menthol
Moisture
Moisture absorption
Natural Materials
Organic Chemistry
Original Research
Physical Chemistry
Polymer Sciences
Polysaccharides
Solubility
Sustainable Development
Swelling
Tensile strength
Terpenes
Wetting
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:In the first stage, seven polysaccharide films were prepared with varying compositions of starch, carboxymethyl starch (CMS), and carboxymethyl cellulose (CMC), together with glycerol and citric acid. From these samples, the most suitable film for possible future applications in medicine in the form of patches was selected based on tensile strength tests, solubility in water, moisture sorption, swelling, and wetting angle. This film (labelled as “V”) contained (in wt%) CMS (2.5), CMC (2.5), citric acid (3), and glycerol (3). In the second stage, the selected film was used for further applications by individually introducing into it appropriate additives with known antimicrobial activity. These additives consisted of terpene compounds of natural origin (α-pinene, menthol, and eugenol) as well as colloidal silver. These four films were then studied to determine the influence of the appropriate additive on moisture absorption, solubility in water, swelling, and antimicrobial activity. The results of the microbiological tests confirmed the antimicrobial activities, and also the anti-infective and regenerative effect of these films. In general, the films containing terpenes showed comparable or better medicinal properties than the film obtained with colloidal silver. A patch prototype (with a medical net) based on the optimal film (“V”) was developed, and its flexibility is apparent in that it can take the shape and size of the area on the human body that it should cover. Graphical Abstract
ISSN:0969-0239
1572-882X
DOI:10.1007/s10570-021-04008-0