Distribution patterns of intramyocellular and extramyocellular fat by magnetic resonance imaging in subjects with diabetes, prediabetes and normoglycaemic controls

Aim To evaluate the distribution of intramyocellular lipids (IMCLs) and extramyocellular lipids (EMCLs) as well as total fat content in abdominal skeletal muscle by magnetic resonance imaging (MRI) using a dedicated segmentation algorithm in subjects with type 2 diabetes (T2D), prediabetes and normo...

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Published in:Diabetes, obesity & metabolism obesity & metabolism, 2021-08, Vol.23 (8), p.1868-1878
Main Authors: Kiefer, Lena S., Fabian, Jana, Rospleszcz, Susanne, Lorbeer, Roberto, Machann, Jürgen, Kraus, Mareen S., Roemer, Frank, Rathmann, Wolfgang, Meisinger, Christa, Heier, Margit, Nikolaou, Konstantin, Peters, Annette, Storz, Corinna, Diallo, Thierno D., Schlett, Christopher L., Bamberg, Fabian
Format: Article
Language:English
Subjects:
body composition
Body mass index
Cohort analysis
cohort study
Diabetes
Diabetes mellitus (non-insulin dependent)
Glucose metabolism
Image processing
Lipids
Magnetic resonance imaging
Metabolism
Musculoskeletal system
Obesity
Segmentation
Skeletal muscle
type 2 diabetes
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Summary:Aim To evaluate the distribution of intramyocellular lipids (IMCLs) and extramyocellular lipids (EMCLs) as well as total fat content in abdominal skeletal muscle by magnetic resonance imaging (MRI) using a dedicated segmentation algorithm in subjects with type 2 diabetes (T2D), prediabetes and normoglycaemic controls. Materials and Methods Subjects from a population‐based cohort were classified with T2D, prediabetes or as normoglycaemic controls. Total myosteatosis, IMCLs and EMCLs were quantified by multiecho Dixon MRI as proton‐density fat‐fraction (in %) in abdominal skeletal muscle. Results Among 337 included subjects (median age 56.0 [IQR: 49.0‐64.0] years, 56.4% males, median body mass index [BMI]: 27.2 kg/m2), 129 (38.3%) were classified with an impaired glucose metabolism (T2D: 49 [14.5%]; prediabetes: 80 [23.7%]). IMCLs were significantly higher than EMCLs in subjects without obesity (5.7% [IQR: 4.8%‐7.0%] vs. 4.1% [IQR: 2.7%‐5.8%], P 
ISSN:1462-8902
1463-1326
DOI:10.1111/dom.14413