Inflammatory Lesions: Cyclic Arginine–Glycine–Aspartate‐Decorated Lipid Nanoparticle Targeting toward Inflammatory Lesions Involves Hitchhiking with Phagocytes (Adv. Sci. 13/2021)

In article number 2100370, Alexandros Marios Sofias, Sjoerd Hak, and co‐workers, report that cRGD‐decorated lipid nanoparticles target inflammatory lesions via hitchhiking with phagocytes. Through a complementary approach including state‐of‐the‐art intravital microscopy, it is identified that neutro...

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Bibliographic Details
Published in:Advanced science 2021-07, Vol.8 (13), p.n/a
Main Authors: Sofias, Alexandros Marios, Bjørkøy, Geir, Ochando, Jordi, Sønstevold, Linda, Hegvik, Maria, Davies, Catharina de Lange, Haraldseth, Olav, Lammers, Twan, Mulder, Willem J. M., Hak, Sjoerd
Format: Article
Language:English
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Summary:In article number 2100370, Alexandros Marios Sofias, Sjoerd Hak, and co‐workers, report that cRGD‐decorated lipid nanoparticles target inflammatory lesions via hitchhiking with phagocytes. Through a complementary approach including state‐of‐the‐art intravital microscopy, it is identified that neutrophils and monocytes take up cRGD‐decorated liposomes and nanoemulsions in circulation and subsequently home to the inflammatory lesion. Cover art: flowers (red) resemble phagocytes loaded with cRGD‐decorated lipid nanoparticles in the inflammatory lesion, grass (green) resembles the inflammatory lesion, foot‐path (yellow) resembles a blood vessel proximal to the inflamed tissue. Top‐right: distant view of the Norwegian University of Science and Technology (NTNU) campus.
ISSN:2198-3844
2198-3844
DOI:10.1002/advs.202170077