Inflammatory Lesions: Cyclic Arginine–Glycine–Aspartate‐Decorated Lipid Nanoparticle Targeting toward Inflammatory Lesions Involves Hitchhiking with Phagocytes (Adv. Sci. 13/2021)

In article number 2100370, Alexandros Marios Sofias, Sjoerd Hak, and co‐workers, report that cRGD‐decorated lipid nanoparticles target inflammatory lesions via hitchhiking with phagocytes. Through a complementary approach including state‐of‐the‐art intravital microscopy, it is identified that neutro...

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Published in:Advanced science 2021-07, Vol.8 (13), p.n/a
Main Authors: Sofias, Alexandros Marios, Bjørkøy, Geir, Ochando, Jordi, Sønstevold, Linda, Hegvik, Maria, Davies, Catharina de Lange, Haraldseth, Olav, Lammers, Twan, Mulder, Willem J. M., Hak, Sjoerd
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container_issue 13
container_start_page
container_title Advanced science
container_volume 8
creator Sofias, Alexandros Marios
Bjørkøy, Geir
Ochando, Jordi
Sønstevold, Linda
Hegvik, Maria
Davies, Catharina de Lange
Haraldseth, Olav
Lammers, Twan
Mulder, Willem J. M.
Hak, Sjoerd
description In article number 2100370, Alexandros Marios Sofias, Sjoerd Hak, and co‐workers, report that cRGD‐decorated lipid nanoparticles target inflammatory lesions via hitchhiking with phagocytes. Through a complementary approach including state‐of‐the‐art intravital microscopy, it is identified that neutrophils and monocytes take up cRGD‐decorated liposomes and nanoemulsions in circulation and subsequently home to the inflammatory lesion. Cover art: flowers (red) resemble phagocytes loaded with cRGD‐decorated lipid nanoparticles in the inflammatory lesion, grass (green) resembles the inflammatory lesion, foot‐path (yellow) resembles a blood vessel proximal to the inflamed tissue. Top‐right: distant view of the Norwegian University of Science and Technology (NTNU) campus.
doi_str_mv 10.1002/advs.202170077
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title Inflammatory Lesions: Cyclic Arginine–Glycine–Aspartate‐Decorated Lipid Nanoparticle Targeting toward Inflammatory Lesions Involves Hitchhiking with Phagocytes (Adv. Sci. 13/2021)
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