CP-177 Switch from intravenous to oral therapy: A prospective study

BackgroundSome of the commonly used anti-infective drugs have excellent oral (PO) bioavailability. The switch from the intravenous (IV) to the PO route, when it is possible, is one of the antimicrobial stewardship recommendations in order to decrease IV complications and nursing workload.PurposeTo d...

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Bibliographic Details
Published in:European journal of hospital pharmacy. Science and practice 2016-03, Vol.23 (Suppl 1), p.A78-A78
Main Authors: Currius, M Vila, Barcons, I Aguilar, Santanach, L Gratacos, Blanch, C Toro, Martinez, M Olmo, Perales, C Batlle, Guell, R Sacrest
Format: Article
Language:English
Subjects:
Antibiotics
Bioavailability
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Summary:BackgroundSome of the commonly used anti-infective drugs have excellent oral (PO) bioavailability. The switch from the intravenous (IV) to the PO route, when it is possible, is one of the antimicrobial stewardship recommendations in order to decrease IV complications and nursing workload.PurposeTo determine the percentage of patients who meet criteria for a switch from the IV to the PO route.To evaluate the acceptance of physicians to the switching recommendations of pharmacists.Material and methodsA prospective observational study was conducted among all adult patients admitted to our hospital from August to September 2015 who received an IV antibiotic with oral bioavailability >75% for a period time of 48–72 h.Available antimicrobial therapy guidelines were reviewed to establish criteria for switching antibiotics from the IV to the PO route. Switching criteria in this study were: (i) acceptable oral tolerance, (ii) haemodynamic stability, iii) clinical improvement (24 h afebrile, leucocytes
ISSN:2047-9956
2047-9964
DOI:10.1136/ejhpharm-2016-000875.177