Efficient visible light mediated synthesis of quinolin-2(1 H )-ones from quinoline N -oxides

Quinolin-2(1 H )-ones are one of the important classes of compounds due to their prevalence in natural products and in pharmacologically useful compounds. Here we present an unconventional and hitherto unknown photocatalytic approach to their synthesis from easily available quinoline- N -oxides. Thi...

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Bibliographic Details
Published in:Green chemistry : an international journal and green chemistry resource : GC 2021-07, Vol.23 (14), p.5049-5055
Main Authors: Mandal, Susanta, Bhuyan, Samuzal, Jana, Saibal, Hossain, Jagir, Chhetri, Karan, Roy, Biswajit Gopal
Format: Article
Language:English
Subjects:
Catalysts
Green chemistry
N-Oxides
Natural products
NMR
Nuclear magnetic resonance
Oxides
Photocatalysis
Quinoline
Reagents
Synthesis
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Summary:Quinolin-2(1 H )-ones are one of the important classes of compounds due to their prevalence in natural products and in pharmacologically useful compounds. Here we present an unconventional and hitherto unknown photocatalytic approach to their synthesis from easily available quinoline- N -oxides. This reagent free highly atom economical photocatalytic method, with low catalyst loading, high yield and no undesirable by-product, provides an efficient greener alternative to all conventional synthesis reported to date. The robustness of the methodology has been successfully demonstrated with easy scaling up to the gram scale.
ISSN:1463-9262
1463-9270
DOI:10.1039/D1GC01460A