Xanthohumol from Hop: Hope for cancer prevention and treatment

Cancer is a major public health concern due to high mortality and poor quality of life of patients. Despite the availability of advanced therapeutic interventions, most treatment modalities are not efficacious, very expensive, and cause several adverse side effects. The factors such as drug resistan...

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Bibliographic Details
Published in:IUBMB life 2021-08, Vol.73 (8), p.1016-1044
Main Authors: Girisa, Sosmitha, Saikia, Queen, Bordoloi, Devivasha, Banik, Kishore, Monisha, Javadi, Daimary, Uzini Devi, Verma, Elika, Ahn, Kwang Seok, Kunnumakkara, Ajaikumar B
Format: Article
Language:English
Subjects:
Aging
AKT protein
Antineoplastic Agents, Phytogenic - pharmacology
Bibliometrics
Cancer
Cell proliferation
Cyclin D1
Diabetes mellitus
Drug resistance
Female
Flavonoids - chemistry
Flavonoids - pharmacokinetics
Flavonoids - pharmacology
Humans
Humulus - chemistry
Insulin-like growth factor-binding protein 2
Male
Neoplasms - drug therapy
Neoplasms - genetics
Neoplasms - metabolism
Neoplasms - pathology
Notch1 protein
Oxidative stress
Propiophenones - chemistry
Propiophenones - pharmacokinetics
Propiophenones - pharmacology
Public health
Quality of life
Signal Transduction - drug effects
Signal Transduction - genetics
Stat3 protein
Therapeutic applications
Xanthohumol
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Summary:Cancer is a major public health concern due to high mortality and poor quality of life of patients. Despite the availability of advanced therapeutic interventions, most treatment modalities are not efficacious, very expensive, and cause several adverse side effects. The factors such as drug resistance, lack of specificity, and low efficacy of the cancer drugs necessitate developing alternative strategies for the prevention and treatment of this disease. Xanthohumol (XN), a prenylated chalcone present in Hop (Humulus lupulus), has been found to possess prominent activities against aging, diabetes, inflammation, microbial infection, and cancer. Thus, this manuscript thoroughly reviews the literature on the anti-cancer properties of XN and its various molecular targets. XN was found to exert its inhibitory effect on the growth and proliferation of cancer cells via modulation of multiple signaling pathways such as Akt, AMPK, ERK, IGFBP2, NF-κB, and STAT3, and also modulates various proteins such as Notch1, caspases, MMPs, Bcl-2, cyclin D1, oxidative stress markers, tumor-suppressor proteins, and miRNAs. Thus, these reports suggest that XN possesses enormous therapeutic potential against various cancers and could be potentially used as a multi-targeted anti-cancer agent with minimal adverse effects.
ISSN:1521-6543
1521-6551
DOI:10.1002/iub.2522