Leishmanicidal activities of biosynthesized BaCO3 (witherite) nanoparticles and their biocompatibility with macrophages

• Published in: Bioprocess and biosystems engineering 2021-09, Vol.44 (9), p.1957-1964
• Main Authors: Hashemi, Nooshin, Alijani, Hajar Q., Mousazadeh, Farideh, Rahi, Sadegh, Darijani, Samaneh, Sharifi, Fatemeh, Khalili, Hakimeh, Iravani, Siavash, Borhani, Fariba, Zafarnia, Niloofar, Khatami, Mehrdad
• Format: Article
• Language: English
• Subjects: Barium; Biocompatibility; Biotechnology; Chemistry; Chemistry and Materials Science; Cytotoxicity; Economic importance; Elderberries; Emission analysis; Environmental Engineering/Biotechnology; Field emission microscopy; Food Science; Immune system; Industrial and Production Engineering; Industrial Chemistry/Chemical Engineering; Macrophages; Morphology; Nanoparticles; Promastigotes; Research Paper; Scanning electron microscopy; Toxicity; X-ray spectroscopy
• ISSN: 1615-7591; 1615-7605
• DOI: 10.1007/s00449-021-02576-w

The aim of this study was cost-effective and greener synthesis of barium carbonate (BaCO 3 or witherite) nanoparticles with economic importance, and to evaluate their therapeutic potentials and biocompatibility with immune cells. Barium carbonate nanoparticles were biosynthesized using black elderberry extract in one step with non-toxic precursors and simple laboratory conditions; their morphologies and specific structures were analyzed using field emission scanning electron microscopy with energy dispersive X-ray spectroscopy (FESEM-EDX). The therapeutic capabilities of these nanoparticles on the immune cells of murine macrophages J774 and promastigotes Leishmania tropica were evaluated. BaCO 3 nanoparticles with IC 50  = 46.6 µg/mL were more effective than negative control and glucantium (positive control) in reducing promastigotes ( P