Application of CALL score for prediction of progression risk in patients with COVID‐19 at university hospital in Turkey

• Published in: International Journal of Clinical Practice 2021-10, Vol.75 (10), p.e14642-n/a
• Main Authors: Erturk Sengel, Buket, Tukenmez Tigen, Elif, Ilgin, Can, Basari, Tugce, Bedir, Merve, Odabasi, Zekaver, Korten, Volkan
• Format: Article
• Language: English
• Subjects: COVID-19; Ferritin; Fibrinogen; Original Paper; ORIGINAL PAPERS; Patients; Polymerase chain reaction; Prediction models
• ISSN: 1368-5031; 1742-1241
• DOI: 10.1111/ijcp.14642

Background The CALL score was developed as a predictive model for progressive disease. We aimed to validate and/or improve the performance of CALL score in our hospital settings. Methods Adult patients with polymerase chain reaction‐confirmed COVID‐19 were included in this retrospective observational study. Clinical and laboratory characteristics (including complete blood count, CRP, ferritin, LDH, fibrinogen, d‐dimer) were obtained. ROC analysis was used for the evaluation of CALL score's performance. Cox regression analyses were performed for the selection of new parameters for improving CALL score. Results Overall, 256 patients were enrolled in the study. The median age was 54 (IQR, 22.5), 134 (52%) were women, 155 (61%) had at least one comorbidity, 60 (23%) had severe disease. The AUC value for CALL score for predicting progression to severe COVID‐19 was 0.59 (95% CI 0.50‐0.66). D‐dimer on admission was associated with progressive disease (HR = 1.2 CI 95% 1.02‐1.40), (P