In Vitro Antiviral Activity of Pinus merkusii (Pinaceae) Stem Bark and Cone against Dengue Virus Type-2 (DENV-2)

Dengue is a major mosquito-borne disease that currently has no effective antiviral or vaccine available. Recently, Indonesia is one of the largest countries in the dengue-endemic region, with a total population of more than 250 million. In the present study, the antiviral activity of P. merkusii ste...

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Bibliographic Details
Published in:Research journal of pharmacy and technology 2021-07, Vol.14 (7), p.3705-3708
Main Authors: Muhammad Ansori, Arif Nur, Fadholly, Amaq, Proboningrat, Annise, Hayaza, Suhailah, Kuncoroningrat Susilo, Raden Joko, Naw, Sin War, Villar Posa, Gabrielle Ann, Firza Yusrizal, Yuhanis, Sibero, Mada Triandala, Hari Sucipto, Teguh, Soegijanto, Soegeng
Format: Article
Language:English
Subjects:
Cancer
Cytotoxicity
Dengue fever
Epidemics
Flavonoids
Herbal medicine
Phytochemicals
Reagents
Tropical diseases
Vaccines
Viral infections
Viruses
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Summary:Dengue is a major mosquito-borne disease that currently has no effective antiviral or vaccine available. Recently, Indonesia is one of the largest countries in the dengue-endemic region, with a total population of more than 250 million. In the present study, the antiviral activity of P. merkusii stem bark and cone were evaluated against dengue virus type-2 (DENV-2; NCBI accession number: KT012509) isolated from Surabaya, Indonesia. We revealed that P. merkusii stem bark and cone inhibited DENV-2 in Vero cells (originally from African green monkey kidney) with IC50= 140.63 μg/mL and 73.78 μg/mL, CC50= 89.65 μg/mL and 249.5 μg/mL, SI= 0.64 and 3.38, respectively. The findings presented here suggest that P. merkusii stem bark and cone exerts potent antiviral activity against DENV-2. Hence, P. merkusii stem bark and cone are potent to inhibit DENV-2 and should be considered for in vivo evaluation in the development of an effective antiviral compound against DENV-2.
ISSN:0974-3618
0974-360X
0974-306X
DOI:10.52711/0974-360X.2021.00641