Adhesion of Candida albicans to Vanillin Incorporated Self-Curing Orthodontic PMMA Resin

It has been observed that there is an increase in Candida carriers during the treatment with orthodontic removable appliance. Vanillin is flavouring agent, which is known to have antioxidant and antimicrobial properties. The aim of this study was to evaluate the effect of vanillin incorporated PMMA...

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Bibliographic Details
Published in:IOP conference series. Materials Science and Engineering 2018-02, Vol.307 (1), p.12013
Main Authors: Zam, K, Sawaengkit, P, Thaweboon, S, Thaweboon, B
Format: Article
Language:English
Subjects:
Adhesion
Antiinfectives and antibacterials
Antioxidants
Curing
Curing agents
Fungicides
Orthodontics
Polymethyl methacrylate
Resins
Statistical analysis
Statistical methods
Vanillin
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Summary:It has been observed that there is an increase in Candida carriers during the treatment with orthodontic removable appliance. Vanillin is flavouring agent, which is known to have antioxidant and antimicrobial properties. The aim of this study was to evaluate the effect of vanillin incorporated PMMA on adhesion of Candida albicans. A total of 36 orthodontic self-curing PMMA resin samples were fabricated. The samples were divided into 3 groups depending on percentage of vanillin incorporated (0.1%, 0.5% and PMMA without vanillin as control). PMMA samples were coated with saliva. The adhesion assay was performed with C. albicans (ATCC 10231). The adherent yeast cells were stained with crystal violet and counted under microscope by random selection of 3 fields at 10X magnification. The statistical analyses performed by Kruskal Wallis and Mann Whitney non-parametric test. It was found that the PMMA resin samples with vanillin incorporation significantly reduced the adhesion of C. albicans as compared to the control group. This study indicates that vanillin incorporated resin can impede the adhesion of C. albicans to about 45 - 56 %. With further testing and development, vanillin can be employed as an antifungal agent to prevent adhesion of C. albicans to orthodontic self-curing PMMA resin.
ISSN:1757-8981
1757-899X
DOI:10.1088/1757-899X/307/1/012013