Regioselective Synthesis of 5H-Benzo[4,5]imidazo[2,1-a]isoindole Linked 1,2,3-Traizole Hybrids and Their Anti-Proliferative Activity

Copper(I) catalyzed regioselective synthesis of some novel 5 H -benzo[4,5]imidazo[2,1- a ]isoindole linked 1,2,3-traizole hybrids has been developed. Structures of the synthesized compounds have been confirmed by IR, 1 H, and 13 C NMR, and mass spectra. The in vitro tests against four human cancer c...

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Bibliographic Details
Published in:Russian journal of general chemistry 2021-06, Vol.91 (6), p.1135-1139
Main Authors: Reddy, M. Srinivas, Swamy, T. Narasimha, Ravinder, M., Nukala, Satheesh Kumar
Format: Article
Language:English
Subjects:
Anticancer properties
Cancer
Chemical synthesis
Chemistry
Chemistry and Materials Science
Chemistry/Food Science
Growth factors
Hydrogen
Hydrogen bonding
In vitro methods and tests
Mass spectra
Molecular docking
NMR
Nuclear magnetic resonance
Regioselectivity
Triazoles
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Summary:Copper(I) catalyzed regioselective synthesis of some novel 5 H -benzo[4,5]imidazo[2,1- a ]isoindole linked 1,2,3-traizole hybrids has been developed. Structures of the synthesized compounds have been confirmed by IR, 1 H, and 13 C NMR, and mass spectra. The in vitro tests against four human cancer cell lines, MCF-7, HeLa, A549, and IMR32, have exhibited notable anticancer activity of some products comparable with that of the standard drug etoposide. Molecular docking studies carried out with epidermal growth factor receptor (PDB ID- 4HJO) have supported anticancer activity of the compounds.
ISSN:1070-3632
1608-3350
DOI:10.1134/S1070363221060232