The diagnostic value of circulating microRNA-499 versus high-sensitivity cardiac troponin T in early diagnosis of ST segment elevation myocardial infarction

Background Ischemic heart disease is the single most common cause of death worldwide. In order to increase the accuracy of the diagnosis, new diagnostic methods have been introduced, including miRNA-499, which is a promising biomarkers in coronary atherosclerotic diseases (CAD), and acute myocardial...

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Bibliographic Details
Published in:Comparative clinical pathology 2021-08, Vol.30 (4), p.565-570
Main Authors: Abdou, Doaa M., Aziz, Emmanuel E., Kazem, Yousif S., Elgabrty, Safaa, Taha, Hesham S.
Format: Article
Language:English
Subjects:
Arteriosclerosis
Biomarkers
Calcium-binding protein
Coronary artery disease
Diagnosis
Emergency medical care
Heart attacks
Heart diseases
Hematology
Ischemia
Medical diagnosis
Medicine
Medicine & Public Health
MicroRNAs
miRNA
Myocardial infarction
Oncology
Original Article
Pathology
Reverse transcription
Troponin
Troponin T
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Summary:Background Ischemic heart disease is the single most common cause of death worldwide. In order to increase the accuracy of the diagnosis, new diagnostic methods have been introduced, including miRNA-499, which is a promising biomarkers in coronary atherosclerotic diseases (CAD), and acute myocardial infarction (AMI). Aim of the work To evaluate the diagnostic value of circulating miRNA-499 versus high-sensitivity cardiac troponin in early diagnosis of AMI with ST segment elevation within the first 6 h of complaint. Subjects and methods This study was conducted on 100 Egyptian patients who presented during the first 3 h of AMI in the emergency department and 98 healthy volunteers as a control group. Serum samples for both groups were analyzed using reverse transcription and real-time PCR by TaqMan® MicroRNA assays. Results The concentration of miRNA-499 was significantly elevated in STEMI patients compared to healthy controls ( p < 0.001). Moreover, receiver operating characteristic (ROC) curve analysis showed that area under the curve (AUC) for miRNA-499 was 0.90 (95% CI, 0.845–0.955) with 89% sensitivity and 83% specificity, at which positive predictive value (PPV) was 94% andnegative predictive value (NPV) was 69%. Furthermore, miRNA-499 displayed significant positive correlation with hs-cTnT and higher expression than hs-cTnT in the first 3 h of chest pain in emergency department. Conclusion miRNA-499 is a promising reliable biomarker for early detection of STEMI patients.
ISSN:1618-5641
1618-565X
DOI:10.1007/s00580-021-03204-5