Introduction of an Oxidation-responsive 4-Boronobenzyl Group into an Oligonucleotide through a Postmodification Approach

Oxidation-responsive oligonucleotides (ONs) can exhibit controlled functions by sensing dysregulated oxidation conditions in living systems. Herein, we describe a postmodification approach to constructing an oxidation-responsive ON that takes advantage of the reactivity of diazo compounds in introdu...

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Bibliographic Details
Published in:Chemistry letters 2021-07, Vol.50 (7), p.1412-1415
Main Authors: Shirakami, Nanami, Kawaki, Yugo, Higashi, Sayuri L., Shibata, Aya, Kitamura, Yoshiaki, Abu Hanifah, Sharina, Wah, Lim Lee, Ikeda, Masato
Format: Article
Language:English
Subjects:
Oligonucleotides
Oxidation
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Summary:Oxidation-responsive oligonucleotides (ONs) can exhibit controlled functions by sensing dysregulated oxidation conditions in living systems. Herein, we describe a postmodification approach to constructing an oxidation-responsive ON that takes advantage of the reactivity of diazo compounds in introducing a 4-boronobenzyl group to a phosphate group at a 5′-terminal of an ON.
ISSN:0366-7022
1348-0715
DOI:10.1246/cl.210204