Mentzer Index Diagnostic Value in Predicting Thalassemia Diagnosis

Thalassemia diagnosis requires gen examination using Polymerase Chain Reaction (PCR) device or hemoglobin (Hb) electrophoresis using electrophoresis or High Performance Liquid Chromatography (HPLC) device which is only available in certain hospitals. Therefore, it is important to develop easily exam...

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Bibliographic Details
Published in:IOP conference series. Earth and environmental science 2019-05, Vol.255 (1), p.12004
Main Authors: Siswandari, W, Rujito, L, Indriani, V, Djatmiko, W
Format: Article
Language:English
Subjects:
Anemia
Blood diseases
Diagnosis
Diagnostic systems
diagnostic value
Electrophoresis
Hemoglobin
High performance liquid chromatography
Liquid chromatography
Mentzer Index
Polymerase chain reaction
Thalassemia
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Summary:Thalassemia diagnosis requires gen examination using Polymerase Chain Reaction (PCR) device or hemoglobin (Hb) electrophoresis using electrophoresis or High Performance Liquid Chromatography (HPLC) device which is only available in certain hospitals. Therefore, it is important to develop easily examined parameters which are useful to assess thalassemia carrier diagnosis. This study aims at figuring out the diagnostic value of Mentzer Index in predicting beta-thalassemia carrier compared to the results of HB electrophoresis examination. Data were taken from 37 anemia patients at Prof. Dr. Margono Soekarjo Regional Public Hospital in Purwokerto who underwent Hb electrophoresis examination using electrophoresis instrument and routine blood count. Furthermore, Mentzer Index was calculated, odds ratio (OR) was analyzed, and diagnostic values were compared to the results of Hb electrophoresis. Mentzer index OR value was 2.4 (0.5 - 11.5, CI95%). Mentzer Index sensitivity (Sn) was 0.36 with specificity (Sp) at 0.81, positive predictive value (PPV) at 0.44 and negative predictive value (NPV) at 0.75. Mentzer index could be used to predict the diagnosis of beta-thalassemia carrier.
ISSN:1755-1307
1755-1315
1755-1315
DOI:10.1088/1755-1315/255/1/012004