Synthesis and antimicrobial and antinociceptive activity of 4-substituted 2-trichloromethyl-3H-1,5-benzodiazepines

The reaction of 1-substituted 4,4,4-trichloromethylbutane-1,3-diones with o -phenylenediamine afforded 4-substituted 2-trichloromethyl-3 H -1,5-benzodiazepines with antimicrobial and antinociceptive activities.

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Bibliographic Details
Published in:Russian chemical bulletin 2021-07, Vol.70 (7), p.1408-1414
Main Authors: Myshkina, O. A., Balandina, S. Yu, Makhmudov, R. R., Dmitriev, M. V., Lisovenko, N. Yu
Format: Article
Language:English
Subjects:
Antiinfectives and antibacterials
Benzodiazepines
Chemistry
Chemistry and Materials Science
Chemistry/Food Science
Full Articles
Inorganic Chemistry
Organic Chemistry
Phenylenediamine
Substitutes
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Description
Summary:The reaction of 1-substituted 4,4,4-trichloromethylbutane-1,3-diones with o -phenylenediamine afforded 4-substituted 2-trichloromethyl-3 H -1,5-benzodiazepines with antimicrobial and antinociceptive activities.
ISSN:1066-5285
1573-9171
DOI:10.1007/s11172-021-3232-1