Synthesis, X-ray structure and biological activity of mono- and dinuclear copper complexes derived from N-{2-[(2-diethylamino(alkyl)imino)-methyl]-phenyl}-4-methyl-benzenesulfonamide

[Display omitted] •Cu(II) complexes of N-{2-[(2-diethylaminoalkylimino)methyl]phenyl}-4-tosylsulfonamide were obtained.•Copper ions have either a distorted square planar or square pyramidal environment.•The obtained copper complexes exhibit high protistocidal activity. A series of copper(II) complex...

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Bibliographic Details
Published in:Inorganica Chimica Acta 2021-08, Vol.523, p.120408, Article 120408
Main Authors: Vlasenko, Valery G., Burlov, Anatolii S., Koshchienko, Yurii V., Kolodina, Alexandra A., Chaltsev, Bogdan V., Zubavichus, Yan V., Khrustalev, Victor N., Danilenko, Tatyana N., Zubenko, Alexander A., Fetisov, Leonid N., Klimenko, Alexander I.
Format: Article
Language:English
Subjects:
Absorption spectroscopy
Azomethines
Biological activity
Chemical analysis
Coordination compounds
Copper chloride
Copper compounds
Copper(II) complex
Crystal structure
Crystals
E coli
Fungi
Imines
Infrared analysis
Infrared spectroscopy
Single crystals
Sodium azides
Spectrum analysis
Synthesis
X ray absorption
X-ray absorption spectroscopy
X-ray diffraction
X-ray spectroscopy
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Summary:[Display omitted] •Cu(II) complexes of N-{2-[(2-diethylaminoalkylimino)methyl]phenyl}-4-tosylsulfonamide were obtained.•Copper ions have either a distorted square planar or square pyramidal environment.•The obtained copper complexes exhibit high protistocidal activity. A series of copper(II) complexes with new Schiff bases, namely N-{2-[(2-diethylamino(alkyl)imino)-methyl]-phenyl}-4-methylbenzenesulfonamide [alkyl = ethyl (HL1) or propyl (HL2)], were synthesized using copper acetate or chloride and characterized by elemental analysis, IR and X-ray absorption spectroscopy, and single-crystal X-ray diffraction. The coordination geometry around the Cu(II) ion in Cu(L1)2 and Cu(L2)2 was studied by X-ray absorption spectroscopy. The crystal structures of copper(II) complexes with L1 ligand synthesized from copper chloride and copper acetate with addition of sodium azide have been determined by X-ray diffraction. The azomethines and all copper(II) complexes have been screened for their antibacterial, protistocidal, and fungistatic activities against Penicillium italicum, Colpoda steinii, Escherichia coli 078, and Staphylococcus aureus P-209.
ISSN:0020-1693
1873-3255
DOI:10.1016/j.ica.2021.120408