Non-coding RNA: insights into the mechanism of methamphetamine neurotoxicity

Chronic exposure of the methamphetamine has been shown to lead to neurotoxicity in rodents and humans. The manifestations of methamphetamine neurotoxicity include methamphetamine use disorder, methamphetamine abuse, methamphetamine addiction and methamphetamine behavioral sensitization. Repeated use...

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Bibliographic Details
Published in:Molecular and cellular biochemistry 2021-09, Vol.476 (9), p.3319-3328
Main Authors: Gu, Ying-Jian, Chen, Lei, Cheng, Lin, Zhou, Ming-Yuan, Wang, Yun
Format: Article
Language:English
Subjects:
Addictions
Biochemistry
Biomedical and Life Sciences
Cardiology
Chronic exposure
Drug abuse
Epidemics
Gene expression
Life Sciences
Medical Biochemistry
Methamphetamine
Neurotoxicity
Non-coding RNA
Nucleus accumbens
Oncology
RNA
Ventral tegmentum
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Summary:Chronic exposure of the methamphetamine has been shown to lead to neurotoxicity in rodents and humans. The manifestations of methamphetamine neurotoxicity include methamphetamine use disorder, methamphetamine abuse, methamphetamine addiction and methamphetamine behavioral sensitization. Repeated use of methamphetamine can cause methamphetamine use disorder. The abuse and addiction of methamphetamine are growing epidemic worldwide. Repeated intermittent exposure to methamphetamine can cause behavioral sensitization. In addition, many studies have shown that changes in the expression of non-coding RNA in the ventral tegmental area and nucleus accumbens will affect the behavioral effects of methamphetamine. Non-coding RNA plays an important role in the behavioral effects of methamphetamine. Therefore, it is important to study the relationship between methamphetamine and non-coding RNA. The purpose of this review is to study the non-coding RNA associated with methamphetamine neurotoxicity to search for the possible therapeutic target of the methamphetamine neurotoxicity.
ISSN:0300-8177
1573-4919
DOI:10.1007/s11010-021-04160-y