Development and in vitro evaluation of carboxymethyl chitosan based drug delivery system for the controlled release of propranolol hydrochloride

Propranolol hydrochloride is a nonselective β-adrenergic drug and has been used as angina pectoris, antihypertensive, and that of many other cardiovascular disorders. It has a relatively short plasma half-life and duration of action are considered too short in certain circumstances. Thus, it's...

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Bibliographic Details
Published in:IOP conference series. Earth and environmental science 2017-12, Vol.101 (1), p.12038
Main Authors: Hernawan, Hayati, Septi Nur, Nisa, Khoirun, Indrianingsih, Anastasia Wheni, Darsih, Cici, Kismurtono, Muhammad
Format: Article
Language:English
Subjects:
Angina
Angina pectoris
Chitosan
Compression
Controlled release
Drug delivery
Drug delivery systems
Friability
Granulation
In vitro methods and tests
Physical properties
Propanolol hydrochloride
Propranolol
Tablets
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Summary:Propranolol hydrochloride is a nonselective β-adrenergic drug and has been used as angina pectoris, antihypertensive, and that of many other cardiovascular disorders. It has a relatively short plasma half-life and duration of action are considered too short in certain circumstances. Thus, it's fascinating to elongate the action. The tablet formula was based on extended-release by a propranolol hydrochloride based carboxymethyl chitosan matrix. Here we used direct compression technique with internal wet granulation to prepare the tablets. The tablets were evaluated for physical properties (hardness, weight variation test, friability) and in vitro release studies. There was no interaction observed between propranolol hydrochloride and excipients. Dissolution profiles of each formulation were followed zero order model. In conclusion, these results strongly suggest that in appropriate proportions carboxymethyl chitosan with internal granulation is suitable for formulating propranolol hydrochloride controlled release.
ISSN:1755-1307
1755-1315
DOI:10.1088/1755-1315/101/1/012038