Social Environment Ameliorates Behavioral and Immune Impairments in Tyrosine Hydroxylase Haploinsufficient Female Mice

The social environment can influence the functional capacity of nervous and immune systems, and consequently the state of health, especially in aged individuals. Adult female tyrosine hydroxylase haploinsufficient (TH-HZ) mice exhibit behavioral impairments, premature immunosenescence and oxidative-...

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Bibliographic Details
Published in:Journal of neuroimmune pharmacology 2021-09, Vol.16 (3), p.548-566
Main Authors: Garrido, A., Cruces, J., Ceprián, N., Hernández-Sánchez, C., De Pablo, F., De la Fuente, Mónica
Format: Article
Language:English
Subjects:
Animals
Anxiety
Behavior
Biomedical and Life Sciences
Biomedicine
Cell Biology
Female
Haploinsufficiency
Immunology
Longevity
Mice
Neurosciences
Original Article
Oxidative Stress
Pharmacology/Toxicology
Rodents
Social Environment
Tyrosine 3-Monooxygenase
Virology
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Summary:The social environment can influence the functional capacity of nervous and immune systems, and consequently the state of health, especially in aged individuals. Adult female tyrosine hydroxylase haploinsufficient (TH-HZ) mice exhibit behavioral impairments, premature immunosenescence and oxidative- inflammatory stress. All these deteriorations are associated with a lower lifespan than wild type (WT) counterparts. The aim was to analyze whether the cohabitation with WT animals could revert or at least ameliorate the deterioration in the nervous and immune systems that female TH-HZ mice show at adult age. Female TH-HZ and WT mice at age of 3–4 weeks were divided into following groups: control TH-HZ (5 TH-HZ mice in the cage; TH-HZ100%), control WT (5 WT mice in the cage; WT100%), TH-HZ > 50% and WT 
ISSN:1557-1890
1557-1904
DOI:10.1007/s11481-020-09947-2