Role of the S100 protein family in liver disease (Review)

Liver disease is a significant health challenge worldwide and comprises liver fibrosis and cirrhosis, viral hepatitis, fatty liver, non-alcoholic fatty liver disease, alcoholic liver disease and hepatocellular carcinoma (HCC). Due to the lack of effective treatments, the prognosis of end-stage liver...

Full description

Saved in:
Bibliographic Details
Published in:International journal of molecular medicine 2021-09, Vol.48 (3), p.1, Article 166
Main Authors: Yao, Shun, Yang, Xingyue, An, Jiaxing, Jin, Hai, Wen, Guorong, Wang, Hui, Tuo, Biguang
Format: Article
Language:English
Subjects:
Apoptosis
Biomarkers
Breast cancer
Cell cycle
Chromosomes
Cytokines
Development and progression
Fibroblasts
Growth factors
Health aspects
Hepatitis
Hepatitis B
Inflammation
Liver cancer
Liver cirrhosis
Liver diseases
Physiology
Prognosis
Protein binding
Protein expression
Proteins
Tumors
Viral infections
Virus diseases
Citations: Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Liver disease is a significant health challenge worldwide and comprises liver fibrosis and cirrhosis, viral hepatitis, fatty liver, non-alcoholic fatty liver disease, alcoholic liver disease and hepatocellular carcinoma (HCC). Due to the lack of effective treatments, the prognosis of end-stage liver disease (including advanced liver cirrhosis and HCC) is often poor. S100 proteins are a type of [Ca.sup.2+] binding protein, which are expressed in a cell-specific manner in vertebrates. These proteins are involved in numerous functions, such as serving as intracellular [Ca.sup.2+] sensors, transduction of [Ca.sup.2+] signals and regulation of extracellular factors that affect cellular activity by binding to a range of membrane receptors. Evidence has shown that S100 proteins serve key roles in the occurrence and development of liver disease and can be used as potential therapeutic targets or diagnosis markers. For example, certain studies have suggested that blocking S100 protein expression may be an innovative treatment strategy. The present review focuses on the functions of the S100 protein family in liver disease. Key words: S100, liver disease, hepatocellular carcinoma, diagnostic marker, therapeutic target
ISSN:1107-3756
1791-244X
DOI:10.3892/ijmm.2021.4999