Copper Nanoparticles as Growth Promoter, Antioxidant and Anti-Bacterial Agents in Poultry Nutrition: Prospects and Future Implications

• Published in: Biological trace element research 2021-10, Vol.199 (10), p.3825-3836
• Main Authors: Sharif, Muhammad, Rahman, Muhammad Aziz-ur, Ahmed, Bilal, Abbas, Rao Zahid, Hassan, Faiz-ul
• Format: Article
• Language: English
• Subjects: Animals; Anti-Bacterial Agents; Antibacterial agents; Antibiotics; Antiinfectives and antibacterials; Antioxidants; Antioxidants - pharmacology; Avian physiology; Bacteria; Bioavailability; Biochemistry; Biomedical and Life Sciences; Biotechnology; Conversion ratio; Copper; Copper - pharmacology; Digestibility; Dosage; Economic impact; Economics; Feed conversion; Food conversion; Growth; Immune system; Immunity; Life Sciences; Metal Nanoparticles; Nanoparticles; Nanotechnology; Nutrient status; Nutrition; Oncology; Physiological functions; Physiology; Pollution; Poultry; Poultry nutrition; Promoters; Toxicology; Trace minerals
• ISSN: 0163-4984; 1559-0720
• DOI: 10.1007/s12011-020-02485-1

Copper (Cu) is a vital trace mineral involved in many physiological functions of the body. In the poultry industry, copper sulfate is being used as a major source of Cu. Copper in the bulk form is less available in the body, and much of its amount excreted out with feces causing environmental pollution and economic loss. The application of nanotechnology offers promise to address these issues by making nanoparticles. Copper nanoparticles (Cu-NP) are relatively more bioavailable due to their small size and high surface to volume ratio. Although, there is limited research on the use of Cu-NP in the poultry industry. Some researchers have pointed out the importance of Cu-NP as an effective alternative of chemical, anti-bacterial agents, and growth promoters. The effect of Cu-NP depends on their size, dose rate and the synthesis method. Apart from there, high bioavailability Cu-NP exhibited positive effects on the immunity of the birds. However, some toxic effects of Cu-NP have also been reported. Further investigations are essentially required to provide mechanistic insights into the role of Cu-NP in the avian physiology and their toxicological properties. This review aims to highlight the potential effects of Cu-NP on growth, immune system, antioxidant status, nutrient digestibility, and feed conversion ratio in poultry. Moreover, we have also discussed the future implications of Cu-NP as a growth promoter and alternative anti-bacterial agents in the poultry industry.