Metabolic annotation, interactions and characterization of natural products of mango (Mangifera indica L.): 1H NMR based chemical metabolomics profiling

• Published in: Process biochemistry (1991) 2021-09, Vol.108, p.18-25
• Main Authors: Angamuthu, Sudha, R. Ramaswamy, Chidambaram, Thangaswamy, Selvankumar, Sadhasivam, Deepa Rani, Nallaswamy, Veeraiyan Deepak, Subramanian, Raghunandhakumar, Ganesan, Raja, Raju, Amutha
• Format: Article
• Language: English
• Subjects: Amino acids; Annotations; Arid zones; Complications; Diarrhea; Diet; Fatty acids; Fertilization; Flavonoids; Fruits; Glutathione; Homeostasis; Machine learning; Mangifera indica; Mangifera indica L; Mangoes; Metabolic pathways; Metabolic phenotyping; Metabolism; Metabolites; Metabolomics; Natural products; Network analysis; NMR; NMR spectroscopy; Nuclear magnetic resonance; Organic compounds; Oxidative stress; Pattern analysis; Pattern recognition; Phenolic acids; Phenols; Phytochemicals; Trimethylamine
• ISSN: 1359-5113; 1873-3298
• DOI: 10.1016/j.procbio.2021.05.024

[Display omitted] •High-resolution metabolomics detected metabolic activity in Mangifera indica L. with different environments.•Adverse outcomes occur as combination of 1H-NMR spectral data, multivariate data analysis, and profiling analysis.•Metabolic pathway perturbations related to cellular dysfunctions can found.•Interdisciplinary data science in Mangifera indica L. can address challenges of metabolites analysis. We examine the relationship between wetland (WL) and dryland (DL) Mangifera indica L with dietary-induced metabolic homeostasis. The typical Indian mango fruit Mangifera indica L has shown promise in the prevention of diarrhea and its complications. However, there is little information available regarding the characterization of organic compounds, metabolites, small molecules, and phytochemicals derived from Mangifera indica L. (Mango). In this study, we performed a global target profiling investigation of phytochemicals and inhibitors in Mangifera indica L.using proton nuclear magnetic resonance (1H NMR) signals. The glutathione (GSH), trimethylamine-N-oxcide (TMAO), and trimethylamine (TMO) are associated with disruptions of oxidative stress metabolisms. Metabolic differences of WL and DL mango were investigated with network analysis for revealing their metabolic discriminations. During plant life, fertilization, and biotic and abiotic stress reflected peculiar metabolomic profiles. The methodology is highly efficient, complex deconvolution, spectral baseline fitting that has transported to pattern recognition analysis. Fifty metabolites were identified and characterized which includes xanthones, phenolic acids, fatty acids, flavonoids, and amino acids. The current study is the first report of metabolites reglation by mango fruits. In conclusion, from Indian traditional mango fruits, we provide a perspective of metabolomic impacts and associated metabolic pathways with high-throughput analytical analysis.