Comparison of DNA damage level in irradiated blood cells of mouse, frog and human

Here, we present the comparative studies of DNA damage induced by X-ray irradiation in vitro in mouse, frog and human blood cells and assessed by the "comet test" (alkaline version). We showed that, in contrast to mouse and human cells, DNA repair processes in frog blood cells are not comp...

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Bibliographic Details
Published in:IOP conference series. Materials Science and Engineering 2019-03, Vol.487 (1), p.12016
Main Authors: Mitroshina, I Y, Sirota, N P, Kuznetsova, E A
Format: Article
Language:English
Subjects:
Blood
Blood cells
Comparative studies
DNA damage
Frogs
Radiation
Radiation damage
X ray irradiation
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Summary:Here, we present the comparative studies of DNA damage induced by X-ray irradiation in vitro in mouse, frog and human blood cells and assessed by the "comet test" (alkaline version). We showed that, in contrast to mouse and human cells, DNA repair processes in frog blood cells are not completed by 60 minutes of the post-radiation period. The results suggest that frogs can be used as indicators of environmental radiation pollution. In this regard, additional experiments are needed to assess the different types of external and internal exposure of animals.
ISSN:1757-8981
1757-899X
1757-899X
DOI:10.1088/1757-899X/487/1/012016