Comparison of DNA damage level in irradiated blood cells of mouse, frog and human

Here, we present the comparative studies of DNA damage induced by X-ray irradiation in vitro in mouse, frog and human blood cells and assessed by the "comet test" (alkaline version). We showed that, in contrast to mouse and human cells, DNA repair processes in frog blood cells are not comp...

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Published in:IOP conference series. Materials Science and Engineering 2019-03, Vol.487 (1), p.12016
Main Authors: Mitroshina, I Y, Sirota, N P, Kuznetsova, E A
Format: Article
Language:English
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Blood
Blood cells
Comparative studies
DNA damage
Frogs
Radiation
Radiation damage
X ray irradiation
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Sirota, N P
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description Here, we present the comparative studies of DNA damage induced by X-ray irradiation in vitro in mouse, frog and human blood cells and assessed by the "comet test" (alkaline version). We showed that, in contrast to mouse and human cells, DNA repair processes in frog blood cells are not completed by 60 minutes of the post-radiation period. The results suggest that frogs can be used as indicators of environmental radiation pollution. In this regard, additional experiments are needed to assess the different types of external and internal exposure of animals.
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source Publicly Available Content (ProQuest); Free Full-Text Journals in Chemistry
subjects Blood
Blood cells
Comparative studies
DNA damage
Frogs
Radiation
Radiation damage
X ray irradiation
title Comparison of DNA damage level in irradiated blood cells of mouse, frog and human
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