Synthesis and biological activities of novel S-β-D-glucopyranoside derivatives of 1,2,4-triazole

In this study, 14 novel S-β-D-glucopyranosides of 1,2,4-triazole derivatives were synthesized and characterized by 1 H NMR, 13 C NMR, and HRMS. Then their antifungal activities against Gibberella zeae (G. zeae), Botryosphaeria dothidea (B. dothidea), Phompsis sp., Phytophthora infestans (P. infestan...

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Published in:Phosphorus, sulfur, and silicon and the related elements sulfur, and silicon and the related elements, 2021-08, Vol.196 (7), p.679-684
Main Authors: Chen, Meihang, Lu, Daowang, Zhang, Xun, Chen, Meiyun, Dong, Changjun, Wang, Xian, Wu, Wenneng, Zhang, Guoping, Luo, Hairong
Format: Article
Language:English
Subjects:
1,2,4-triazole
biological activity
Botryosphaeria
Fungicides
NMR
Nuclear magnetic resonance
S-β-D-glucopyranosides
synthesis
Triazoles
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Summary:In this study, 14 novel S-β-D-glucopyranosides of 1,2,4-triazole derivatives were synthesized and characterized by 1 H NMR, 13 C NMR, and HRMS. Then their antifungal activities against Gibberella zeae (G. zeae), Botryosphaeria dothidea (B. dothidea), Phompsis sp., Phytophthora infestans (P. infestans), Thanatephorus cucumeris (T. cucumeris) and antibacterial activities against Xanthomonas oryzae pv. oryzae (Xoo), Xanthomonas citri subsp. citri (Xcc) were evaluated. Bioassay results indicated that most of the title compounds exhibited good antifungal activities. Among them, compounds 4g, 4k, 4m, and 4n showed better antifungal activities against P. infestans with EC 50 values of 4.98, 4.09, 3.85, and 4.90 μg/mL, respectively compared with Dimethomorph (6.06 μg/mL).
ISSN:1042-6507
1563-5325
DOI:10.1080/10426507.2021.1901704