Apoptosis and autophagy modulating dietary phytochemicals in cancer therapeutics: Current evidences and future perspectives

The global incidence of cancer and cancer‐related mortality is expected to rise in recent years despite advancements in cancer diagnosis and therapeutics. Increasing evidences of decrypting molecular mechanisms underlying cancer progression have commanded the tremendous development of synthetic anti...

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Bibliographic Details
Published in:Phytotherapy research 2021-08, Vol.35 (8), p.4194-4214
Main Authors: Patra, Srimanta, Pradhan, Biswajita, Nayak, Rabindra, Behera, Chhandashree, Panda, Krishna Chandra, Das, Surajit, Jena, Mrutyunjay, Bhutia, Sujit Kumar
Format: Article
Language:English
Subjects:
Antineoplastic drugs
Antitumor agents
Apoptosis
Autophagy
Biological activity
Cancer
Chemotherapy
Cytotoxicity
Diet
Dietary supplements
Drug development
Drugs
Food consumption
Medical science
Modulators
Molecular modelling
Phagocytosis
Phytochemicals
Precision medicine
therapeutics
Toxicity
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Summary:The global incidence of cancer and cancer‐related mortality is expected to rise in recent years despite advancements in cancer diagnosis and therapeutics. Increasing evidences of decrypting molecular mechanisms underlying cancer progression have commanded the tremendous development of synthetic anticancer drugs. With limitations in the current conventional cancer therapeutic approaches, the non‐nutritive dietary phytochemicals have emerged as potent modulators of apoptosis and autophagy associated key signaling pathways in various cancer cells. The dynamic regulation of apoptosis and autophagy by phytochemicals in cancer are identified as promising therapeutic candidates with minimal cytotoxicity and enhanced biological activity. Dietary phytochemicals and their synthetic analogs have exhibited potency in the modulation of apoptosis and autophagy in several cancer cells as individuals or in combination with pre‐existing FDA (Food and Drug Administration) approved anticancer drugs. In the current generation of medical science, developing precision and personalized medicine and their consumption as food supplements will hold high prevalence in cancer therapeutics. Hence understating the impact of dietary phytochemicals on human health and their molecular mechanism will thrive a new horizon in cancer therapeutics. Hence, this review has emphasized the role of apoptotic/autophagy modulating dietary phytochemicals in cancer therapy, their preclinical and clinical applications and the future direction of enhanced nano‐formulation for better clinical efficacy.
ISSN:0951-418X
1099-1573
DOI:10.1002/ptr.7082