EFFECT OF HIGH PROTEIN DIET OVER ENERGY EXPENDITURE, THERMOGENIC CYTOKINES AND BAT ACTIVITY

Introduction. The caloric expenditure and thermogenesis are very important aspects in the obesity problem, mostly underestimated. The Protein Leverage Hypothesis (PLH) promotes the effect of satiety, delaying the hunger sensation; thus entails the regulation of caloric intake and body weight, as wel...

Full description

Saved in:
Bibliographic Details
Published in:Annals of nutrition and metabolism 2020-01, Vol.76, p.54
Main Authors: López-Aguilar, I, Figueroa-Vega, N, Pérez-Luque, E, Martínez-Cordero, C, Malacara, J M
Format: Article
Language:English
Subjects:
Adults
Body temperature
Body weight
Body weight loss
Calories
Calorimetry
Clavicle
Creatinine
Cytokines
Diet
Dietary restrictions
Energy expenditure
Evaluation
Flow cytometry
High protein diet
Hunger
Lipids
Low protein diet
Nutrition
Obesity
Physiological effects
Plasma levels
Proteins
Satiety
Thermogenesis
Weight control
Weight loss
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Introduction. The caloric expenditure and thermogenesis are very important aspects in the obesity problem, mostly underestimated. The Protein Leverage Hypothesis (PLH) promotes the effect of satiety, delaying the hunger sensation; thus entails the regulation of caloric intake and body weight, as well as, the modification of thermogenic activity and energy expenditure. However, the effect of high protein diet over the physiological components of energy expenditure has not been evaluated. Objective. To evaluate in adults with obesity the effects of a caloric restriction plan with high protein content (25%) compared with low protein content (10%), over components of energy expenditure and thermogenesis, after 4 weeks of intervention. Methods. We recruited 50 adults with obesity (BMI ≥30kg / m2) aged 20-50, randomized into two diet groups. Before and after the intervention, anthropometric data were measurement. We estimated of caloric expenditure at rest by indirect calorimetry. Temperature measures in the supraclavicular cavity were recorded for 1 hour with the iButton DS1921H device. Glucose, creatinine and lipid profile were detected. Plasma levels of N1-methylnicotinamide(MNA-1) and N1,N12-diacetylspermine were quantified by LCMS. Circulating cytokines were measurement by flow cytometry. Results. At baseline individuals from both groups showed no differences between them. After the intervention, significant reduction in body weight, BMI and waist circumference was observed in both groups (p
ISSN:0250-6807
1421-9697