Recent advances in nanocarriers-based drug delivery for cancer therapeutics: A review

Cancer prevalence is increasing in the last few decades with high mortality rates. It is a leading cause of death globally. Due to the rising prevalence of cancer and the emergence of conventional chemotherapy-related problems, the smart drug delivery system (SDDs) based on intrinsic, extrinsic stim...

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Bibliographic Details
Published in:Reactive & functional polymers 2021-08, Vol.165, p.104970, Article 104970
Main Authors: Yadav, Pinky, Jain, Jigna, Sherje, Atul P.
Format: Article
Language:English
Subjects:
Anticancer properties
Cancer
Cancer therapy
Chemotherapy
Drug carriers
Drug delivery systems
Immune system
Nanomaterials
Polymer based nanocarrier
Side effects
Site-specific delivery
Stimuli
Stimuli responsive
Targeted drug delivery
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Summary:Cancer prevalence is increasing in the last few decades with high mortality rates. It is a leading cause of death globally. Due to the rising prevalence of cancer and the emergence of conventional chemotherapy-related problems, the smart drug delivery system (SDDs) based on intrinsic, extrinsic stimuli-responsive nanocarriers has been widely studied. The current treatment available for cancer has drawbacks such as immune system weakness, irresponsive to treatment, non-specific target. The side effects of anticancer drugs can be reduced by encapsulation of the drug and targeted delivery at the cancer site. Stimuli responsive nanocarriers are effective for drug release at cancer sites to achieve target-specific delivery. These systems show superior ability for targeting cancerous cells without affecting healthy cells and offer the potential for advanced cancer therapies when compared to the conventional system. The present review involves recent advances in intrinsic, extrinsic, and dual-stimuli responsive nanomaterial systems for delivery of drug in cancer therapy. [Display omitted] •Stimuli-responsive nanocarriers are effective for target-specific drug delivery in cancer.•The drug release can be attained at the cancer site in response to stimuli.•Various intrinsic, extrinsic or dual stimuli are used for site-specific delivery of drug.•These delivery systems offer better efficacy in cancer therapy without affecting the normal cells.
ISSN:1381-5148
1873-166X
DOI:10.1016/j.reactfunctpolym.2021.104970