Effects of long-term nonylphenol exposure on myocardial fibrosis and cardiac function in rats

• Published in: Environmental sciences Europe 2021-12, Vol.33 (1), Article 96
• Main Authors: Liu, Chao, Ni, Chengyu, Liu, Weichu, Yang, Xiaolian, Zhang, Renyi, Zhang, Jianling, Luo, Man, Xu, Jie, Yu, Jie
• Format: Article
• Language: English
• Subjects: Aspartate aminotransferase; Biopsy; Cardiovascular diseases; Chronic exposure; Collagen; Collagen (type I); Collagen (type III); Connective tissues; Creatine; Creatine kinase; Dehydrogenase; Dehydrogenases; Dosage; Earth and Environmental Science; Ecotoxicology; Environment; Enzymes; Estrogens; Exposure; Fibrosis; Fractures; Heart; Inflammation; Kinases; L-Lactate dehydrogenase; Lactate dehydrogenase; Lactic acid; Muscles; Myocardium; Natural Toxins - Environmental Fate and Safe Water Supply; Nonylphenol; Pollution; Structure-function relationships; Thickness; Ventricle
• ISSN: 2190-4707; 2190-4715
• DOI: 10.1186/s12302-021-00539-2

Background Myocardial fibrosis is a critical pathological basis for the poor prognosis of cardiovascular diseases. Studies have found that myocardial fibrosis is closely associated with exposure to environmental estrogens such as nonylphenol (NP), as a representative of environmental estrogens. The aim of this study was to examine the effects of NP chronic exposure on myocardial fibrosis as well as cardiac structure and function. Forty Sprague–Dawley rats were randomly divided into four groups ( n  = 10): control group (C), low NP dose (0.4 mg/kg, L), medium NP dose (4 mg/kg, M), and high NP dose (40 mg/kg, H) groups. The NP dose groups were gavaged with NP for 180 days. Results The NP level in the heart of the NP groups was significantly higher than those in the control group ( F  = 43.658, P