Enrichment of Nanodiamond Surfaces with Carboxyl Groups for Doxorubicin Loading and Release

In their pristine state, nanodiamond crystals produced via detonation techniques containing several functional groups present on the surface including amine, amide, alcohol, carbonyl, and carboxyl. These functional groups facilitate nanodiamond to interact drugs so as to nanodiamond is potential for...

Full description

Saved in:
Bibliographic Details
Published in:IOP conference series. Materials Science and Engineering 2017-02, Vol.172 (1), p.12066
Main Authors: Astuti, Y, Saputra, F D, Wuning, S, Arnelli, Bhaduri, G
Format: Article
Language:English
Subjects:
Carbonyls
Detonation
Diamonds
Doxorubicin
Enrichment
Functional groups
Medical research
Nanostructure
Nitric acid
Sulfuric acid
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:In their pristine state, nanodiamond crystals produced via detonation techniques containing several functional groups present on the surface including amine, amide, alcohol, carbonyl, and carboxyl. These functional groups facilitate nanodiamond to interact drugs so as to nanodiamond is potential for medical application such as drug delivery. Even though research on t he use of nanodiamond for this application has been conducted widely, research on the effect of enrichment of nanodiamond surface with carboxyl functional groups for drug loading and release has not been explored extensively. Therefore, in this paper, the effect of carboxyl-terminated nanodiamond (ND-COOH) on drug loading and release will be presented. The enrichment of nanodiamond with carboxyl groups was undertaken by treating nanodiamond with sulphuric acid and nitric acid. The results show that the doxorubicin (DOX) loading and release efficiencies of ND pristine are higher than that of ND-COOH.
ISSN:1757-8981
1757-899X
DOI:10.1088/1757-899X/172/1/012066