Effect of Oral Administration of Tungsten Trioxide (WO3) Particles on Hispathological Feature of liver and kidney in Rat

This study aims to investigate the toxicity and histopathology of tungsten trioxide (WO3) administration on rat's liver and kidney. The LD50 of WO3 was determined and the sub acute toxicity was evaluated by orally administration of 5000 mg kg-1 of WO3 to rat for 14 consecutive days. Parameter o...

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Bibliographic Details
Published in:IOP conference series. Materials Science and Engineering 2017-03, Vol.180 (1), p.12097
Main Authors: Munawaroh, H S H, Nandiyanto, A B D, Gumilar, G G, Widi, A, Subangkit, M
Format: Article
Language:English
Subjects:
Blood cells
Creatinine
Evaluation
Kidneys
Liver
Parameters
Toxicity
Toxicology
Tungsten oxides
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Summary:This study aims to investigate the toxicity and histopathology of tungsten trioxide (WO3) administration on rat's liver and kidney. The LD50 of WO3 was determined and the sub acute toxicity was evaluated by orally administration of 5000 mg kg-1 of WO3 to rat for 14 consecutive days. Parameter of blood cells, ALT, creatinine, and BUN were experimentally measured. The toxicological evaluation showed that WO3 is a non toxic compound with the LD50 higher that 5000 mg kg-1. No biochemical change was observed for creatinine and Blood Urea Nitrogen parameter. In contrast, ALT parameter shows higher value in the experiment than that in the control group. Histopathological changes on rat's liver and kidney were also studied. Small defects in rat's liver and kidney were found, which may interfere the functional of related enzymes.
ISSN:1757-8981
1757-899X
DOI:10.1088/1757-899X/180/1/012097