Gene Expression Risk Scores for COVID-19 Illness Severity

The correlates of COVID-19 illness severity following infection with SARS-Coronavirus 2 (SARS-CoV-2) are incompletely understood. We assessed peripheral blood gene expression in 53 adults with confirmed SARS-CoV-2-infection clinically adjudicated as having mild, moderate or severe disease. Supervise...

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Bibliographic Details
Published in:bioRxiv 2021-08
Main Authors: Peterson, Derick R, Baran, Andrea M, Bhattacharya, Soumyaroop, Branche, Angela R, Croft, Daniel P, Corbett, Anthony M, Walsh, Edward E, Falsey, Ann R, Mariani, Thomas J
Format: Article
Language:English
Subjects:
Cell differentiation
Cell signaling
Coronaviruses
COVID-19
COVID-19 vaccines
Gene expression
Illnesses
Intensive care
Lymphocytes T
Peripheral blood
Principal components analysis
Severe acute respiratory syndrome coronavirus 2
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Summary:The correlates of COVID-19 illness severity following infection with SARS-Coronavirus 2 (SARS-CoV-2) are incompletely understood. We assessed peripheral blood gene expression in 53 adults with confirmed SARS-CoV-2-infection clinically adjudicated as having mild, moderate or severe disease. Supervised principal components analysis was used to build a weighted gene expression risk score (WGERS) to discriminate between severe and non-severe COVID. Gene expression patterns in participants with mild and moderate illness were similar, but significantly different from severe illness. When comparing severe versus non-severe illness, we identified >4000 genes differentially expressed (FDR
ISSN:2692-8205
2692-8205
DOI:10.1101/2021.08.24.457521