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Effect of Proteinase from Aspergillus fumigatus on Blood Plasma Proteins
Extracellular proteinase of the opportunistic Aspergillus fumigatus D-1 strain (molecular weight ~33 kDa, pI 4.6) was isolated. It was shown that proteinase hydrolyzes casein, fibrin, fibrinogen, albumin, and hemoglobin to varying degrees. However, proteolytic activity with respect to globular prote...
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Published in: | Moscow University biological sciences bulletin 2021-04, Vol.76 (2), p.71-76 |
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Main Authors: | , , , , , |
Format: | Article |
Language: | English |
Subjects: | |
Citations: | Items that this one cites Items that cite this one |
Online Access: | Get full text |
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Summary: | Extracellular proteinase of the opportunistic
Aspergillus fumigatus
D-1 strain (molecular weight ~33 kDa, pI 4.6) was isolated. It was shown that proteinase hydrolyzes casein, fibrin, fibrinogen, albumin, and hemoglobin to varying degrees. However, proteolytic activity with respect to globular proteins of blood plasma was comparable to fibrinolytic activity. Proteinase did not coagulate human fibrinogen and bovine fibrinogen; it also did not coagulate human and rabbit blood plasma without dilution and when diluted twice. The plasminogen-activating activity of
A. fumigatus
D-1 extracellular proteinase was found, which may indicate its ability to indirect fibrinolysis. |
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ISSN: | 0096-3925 1934-791X |
DOI: | 10.3103/S0096392521020048 |