Sensitivity and resistance of amperometric biosensors in substrate inhibition processes

•Sensitivity and resistance of amperometric biosensors in substrate inhibition is obtained.•The thickness of the membrane is reported at which the steady-state current gains the maximum value.•The effect of various parameters on sensitivity and resistance are discussed. A theoretical model of a sens...

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Bibliographic Details
Published in:Journal of electroanalytical chemistry (Lausanne, Switzerland) Switzerland), 2021-08, Vol.895, p.115527, Article 115527
Main Authors: Swaminathan, R., Chitra Devi, M., Rajendran, L., Venugopal, K.
Format: Article
Language:English
Subjects:
Amperometric biosensor
Biosensors
Diffusion effects
Diffusion layers
Electrical measurement
Kinetics
Mathematical modeling
Mathematical models
Non-linear equation
Non-michaelis-menten kinetics
Parameters
Sensitivity analysis
Sensitivity and resistance
Substrate inhibition
Thickness
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Summary:•Sensitivity and resistance of amperometric biosensors in substrate inhibition is obtained.•The thickness of the membrane is reported at which the steady-state current gains the maximum value.•The effect of various parameters on sensitivity and resistance are discussed. A theoretical model of a sensitivity and resistance of amperometry biosensors with substrate inhibition kinetics is discussed. This model is based on the system of non-stationary diffusion equations containing a non-linear term related to non-Michaelis-Menten kinetics of the enzymatic reaction. This paper presents the approximate analytical expression of sensitivity and resistance of biosensor for small values of reaction diffusion parameters. The effect various parameters such as thickness of enzyme layer, bulk substrate concentration, Michaelis-Menten and saturation constant on sensitivity and resistance of biosensor are discussed.
ISSN:1572-6657
1873-2569
DOI:10.1016/j.jelechem.2021.115527