Nanotechnology for modern medicine: next step towards clinical translation

The field of nanotechnology has been a significant research focus in the last thirty years. This emphasis is due to the unique optical, electrical, magnetic, chemical and biological properties of materials approximately ten thousand times smaller than the diameter of a hair strand. Researchers have...

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Bibliographic Details
Published in:Journal of internal medicine 2021-09, Vol.290 (3), p.486-498
Main Authors: Sindhwani, Shrey, Chan, Warren C. W.
Format: Article
Language:English
Subjects:
Biological properties
cancer
Chemical compounds
Drug delivery
Drug delivery systems
Feedback loops
Humans
Magnetic properties
Material properties
medicine
Nanomaterials
Nanomedicine - trends
Nanoparticles
Nanotechnology
Optical properties
Partnerships
Pharmacology
Translation
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Summary:The field of nanotechnology has been a significant research focus in the last thirty years. This emphasis is due to the unique optical, electrical, magnetic, chemical and biological properties of materials approximately ten thousand times smaller than the diameter of a hair strand. Researchers have developed methods to synthesize and characterize large libraries of nanomaterials and have demonstrated their preclinical utility. We have entered a new phase of nanomedicine development, where the focus is to translate these technologies to benefit patients. This review article provides an overview of nanomedicine's unique properties, the current state of the field, and discusses the challenge of clinical translation. Finally, we discuss the need to build and strengthen partnerships between engineers and clinicians to create a feedback loop between the bench and bedside. This partnership will guide fundamental studies on the nanoparticle–biological interactions, address clinical challenges and change the development and evaluation of new drug delivery systems, sensors, imaging agents and therapeutic systems.
ISSN:0954-6820
1365-2796
DOI:10.1111/joim.13254