Interaction of cold atmospheric plasma jet with bio targets: different sensitivities of human cell lines

Cold atmospheric plasma (CAP) jet device is developed and CAP jet was applied for the treatment of normal and cancer cells. The characteristics of plasma jet consisting of a sequence of cathode directed streamers are studied in the experiment and numerical fluid model simulations. A content of mixtu...

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Bibliographic Details
Published in:Journal of physics. Conference series 2019-11, Vol.1393 (1), p.12153
Main Authors: Zakrevsky, Dm, Yelak, E, Gugin, P, Golubitskaya, E, Troizkaja, O, Koval, O, Vagapov, S, Schweigert, I
Format: Article
Language:English
Subjects:
Cancer
Chemical reactions
Electric fields
Electron energy
Ion density (concentration)
Physics
Plasma
Plasma jets
Sensitivity
Spatial distribution
Stem cells
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Summary:Cold atmospheric plasma (CAP) jet device is developed and CAP jet was applied for the treatment of normal and cancer cells. The characteristics of plasma jet consisting of a sequence of cathode directed streamers are studied in the experiment and numerical fluid model simulations. A content of mixture of active radicals and ions due to plasma enhanced chemical reactions is calculated with 0D chemical model near the surface of biotarget. The evolution of spatial distribution of the streamer parameters (electric field, electron and ion density, electron energy) delivered by the streamer to the biotarget is calculated. The results of cell viability analysis of normal cells, HEK 293 (kidney embryonic stem cells) and malignant cells, A431 (skin carcinoma) demonstrate the different sensitivity to the indirect CAP jet treatment.
ISSN:1742-6588
1742-6596
DOI:10.1088/1742-6596/1393/1/012153