The Beauty of Gold: Knowledge of Mechanisms Leads to Different Applications of Organogold Compounds in Medicine and Catalysis

This review is aimed at providing a concise overview of the results obtained by our group in the field of organometallic chemistry of gold. Therefore, a selection of examples amongst the most extensively explored families of bioactive gold complexes — Au(I) N-heterocyclic carbenes and cyclometalated...

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Bibliographic Details
Published in:Chemistry letters 2021-08, Vol.50 (8), p.1516-1522
Main Authors: Casini, Angela, Thomas, Sophie R.
Format: Article
Language:English
Subjects:
Aqueous environments
Biological activity
Carbenes
Catalysis
Catalysts
Gold
Organometallic compounds
Vol. 50 Commemorative Highlight Review: Molecular Chemistry
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Summary:This review is aimed at providing a concise overview of the results obtained by our group in the field of organometallic chemistry of gold. Therefore, a selection of examples amongst the most extensively explored families of bioactive gold complexes — Au(I) N-heterocyclic carbenes and cyclometalated Au(III) compounds — is presented. Insights into the bio-inorganic mechanisms of reactivity of organogold compounds obtained by an integrated investigational approach, and knowledge of structure-activity relationships are discussed also in relation to novel applications of gold-based catalysts and metal-mediated transformations in aqueous environment.
ISSN:0366-7022
1348-0715
DOI:10.1246/cl.210238