Particulate matter exposure exacerbates susceptibility to SARS-CoV-2 infection in humanized ACE2 mice

[...]our study demonstrated that PM is an epidemiological factor of COVID-19, emphasizing the necessity of wearing anti-PM masks to cope with this global pandemic. [...]immunoblotting also revealed that the levels of ACE2 and TMPRSS2 were consistently up-regulated in HPAEpiC cells after PM treatment...

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Bibliographic Details
Published in:Dōngwùxué yánjiū 2021-05, Vol.42 (3), p.335-338
Format: Article
Language:English
Subjects:
ACE2
Angiotensin-converting enzyme 2
Coronaviruses
COVID-19
Enzymes
Epidemiology
Experiments
Immunoblotting
Infections
Laboratories
Lungs
Masks
Pandemics
Particulate emissions
Particulate matter
Pathogenesis
Pollutants
Proteins
Science
Severe acute respiratory syndrome coronavirus 2
Suspended particulate matter
Viral diseases
Zoology
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Summary:[...]our study demonstrated that PM is an epidemiological factor of COVID-19, emphasizing the necessity of wearing anti-PM masks to cope with this global pandemic. [...]immunoblotting also revealed that the levels of ACE2 and TMPRSS2 were consistently up-regulated in HPAEpiC cells after PM treatment (Figure 1C). [...]after the SARS-CoV-2-infected hACE2 mice were exposed to PM, the expression of ACE2 and Tmprss2 significantly increased in the lungs. [...]our study demonstrated that PM may be an epidemiological factor of COVID-19, thus emphasizing the necessity of wearing anti-PM masks to help cope with this global pandemic.
ISSN:0254-5853
DOI:10.24272/j.issn.2095-8137.2021.088