Parabiosis modeling: protocol, application and perspectives

Parabiosis is a surgical method of animal modeling with a long history. It has been widely used in medical research, particularly in the fields of aging, stem cells, neuroscience, and immunity in the past two decades. The protocols for parabiosis have been improved many times and are now widely acce...

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Bibliographic Details
Published in:Dōngwùxué yánjiū 2021-05, Vol.42 (3), p.253-261
Main Authors: Yang, Cui, Liu, Zhi-Lan, Wang, Jun, Bu, Xian-Le, Wang, Yan-Jiang, Xiang, Yang
Format: Article
Language:English
Subjects:
Abdomen
Ageing
Aging
Alzheimer's disease
Animal models
Animals
Circulatory system
Immunity
Medical research
Modelling
Nervous system
Neurodegeneration
Neurosciences
Parabiosis
Protocol
Stem cell transplantation
Stem cells
Surgical operations
Sutures
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Summary:Parabiosis is a surgical method of animal modeling with a long history. It has been widely used in medical research, particularly in the fields of aging, stem cells, neuroscience, and immunity in the past two decades. The protocols for parabiosis have been improved many times and are now widely accepted. However, researchers need to consider many details, from surgical operation to perioperative management, to reduce mortality and maintain the parabiosis union. Although parabiosis has certain inevitable limitations, it still has broad application prospects as an irreplaceable animal model in the medical research field.
ISSN:0254-5853
DOI:10.24272/j.issn.2095-8137.2020.368