Tracking Bisphosphonates through a 20 mm Thick Porcine Tissue by Using Surface-Enhanced Spatially Offset Raman Spectroscopy

Track it down: A recognized surface‐enhanced Raman scattering (SERS) nanotag signal was monitored from a thin, dispersed layer of bisphosphonate‐functionalized nanotags on a bone sample, through a 20 mm thick specimen of porcine muscle tissue by surface‐enhanced spatial offset Raman spectroscopy (SE...

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Bibliographic Details
Published in:Angewandte Chemie International Edition 2012-08, Vol.51 (34), p.8509-8511
Main Authors: Xie, Hai-nan, Stevenson, Ross, Stone, Nicholas, Hernandez-Santana, Aaron, Faulds, Karen, Graham, Duncan
Format: Article
Language:English
Subjects:
Animals
Bisphosphonates
Bone and Bones - chemistry
cancer
Diphosphonates - analysis
Diphosphonates - metabolism
Muscles
Nanoparticles - chemistry
nanotags
Neoplasms - chemistry
Neoplasms - metabolism
Raman spectra
Raman spectroscopy
SERS
Signal monitoring
Spectroscopy
Spectrum analysis
Spectrum Analysis, Raman - methods
Swine
Tracking
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Summary:Track it down: A recognized surface‐enhanced Raman scattering (SERS) nanotag signal was monitored from a thin, dispersed layer of bisphosphonate‐functionalized nanotags on a bone sample, through a 20 mm thick specimen of porcine muscle tissue by surface‐enhanced spatial offset Raman spectroscopy (SESORS; see picture). The result demonstrates the great potential for non‐invasive in vivo bisphosphonate drug tracking.
ISSN:1433-7851
1521-3773
DOI:10.1002/anie.201203728