ANTIOXIDANT AND CYTOTOXIC POTENTIAL OF SELECTED PLANT SPECIES OF THE BORAGINACEAE FAMILY

Bioactive components of plants have a potential role in chemoprevention and inhibition of different phases of the malignant transformation process. [...]plant extracts and essential oils are in the focus of research, and in recent decades have been tested on a large number of malignant cell lines. A...

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Published in:Poljoprivreda i šumarstvo 2021-06, Vol.67 (2), p.53-61
Main Authors: BOSKOVIC, Ivana, DJUKIC, Dragutin, MANDIC, Leka, MASKOVIC, Pavle, GOVEDARICA-LUCIC, Aleksandra
Format: Article
Language:English
Subjects:
Anthocyanins
Antioxidants
Berries
Biological activity
Body weight
Camphor
Cancer
Colon
Colon cancer
Cytogenesis
Cytotoxicity
Dehydrogenases
Developed countries
Ellagic acid
Epigenetics
Essential oils
Esters
Ethanol
Factorial experiments
Fibroblasts
Flowers & plants
Free radicals
Fruits
Genetic transformation
Herbal medicine
Larynx
Medical research
Nutrition
Nutrition research
Oils & fats
Phenolic compounds
Phenols
Plant extracts
Plant mitochondria
Plant species
Quercetin
Tumor cell lines
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Summary:Bioactive components of plants have a potential role in chemoprevention and inhibition of different phases of the malignant transformation process. [...]plant extracts and essential oils are in the focus of research, and in recent decades have been tested on a large number of malignant cell lines. According to research by the World Cancer Research Fund, as many as one-third of cancer causes in economically developed countries are related to overweight or obesity, physical inactivity and poor nutrition (American Cancer Society, 2015). Plant-based bioactive phytochemicals are capable of inhibiting tumor cytogenesis through various means by inhibition or modification of epigenetic processes which suppresses gene initiation, suppression and progression (Greenwell and Rahman, 2015). [...]plant extracts and essential oils are in the focus of research, and in recent decades have been tested on a large number of malignant cell lines. Research by Dai and Mumper (2010) confirmed that a diet rich in phenolic compounds significantly reduces the risk of developing malignancies. [...]phenolic extracts of berries (blueberries, blackberries, raspberries, cranberries and strawberries), which contain anthocyanins, camphor, quercetin and esters of coumaric and ellagic acid, have been shown to inhibit the growth of colon cancer cell lines (Seeram et al., 2006; Zhang and Demain, 2005). According to the American National Cancer Institute (NCI), the criterion for cytotoxic activity of plant extracts is IC50
ISSN:0554-5579
1800-9492
DOI:10.17707/AgricultForest.67.2.04