Primary Cranial Vault Lymphoma Extending between Subcutaneous Tissue and Brain Parenchyma without Skull Destruction after Mild Head Trauma: A Case Report and Literature Review

Malignant lymphoma of the head rarely arises outside of the brain parenchyma as primary cranial vault lymphoma (PCVL). A case of PCVL that invaded from subcutaneous tissue into the brain, passing through the skull, and occurred after mild head trauma is reported along with a review of the literature...

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Bibliographic Details
Published in:Case reports in oncology 2021-07, Vol.14 (2), p.1118-1123
Main Authors: Setta, Kengo, Beppu, Takaaki, Sato, Yuichi, Saura, Hiroaki, Nomura, Junichi, Sugai, Tamotsu, Ogasawara, Kuniaki
Format: Article
Language:English
Subjects:
Brain cancer
Case Report
Case reports
Contrast agents
diffuse large b-cell lymphoma
Head injuries
head trauma
Literature reviews
Lymphoma
Magnetic resonance imaging
Metastasis
Nervous system
primary cranial vault lymphoma
Skull
Surgery
Trauma
Tumors
Veins & arteries
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Summary:Malignant lymphoma of the head rarely arises outside of the brain parenchyma as primary cranial vault lymphoma (PCVL). A case of PCVL that invaded from subcutaneous tissue into the brain, passing through the skull, and occurred after mild head trauma is reported along with a review of the literature. The patient was a 75-year-old man with decreased activity. One month before his visit to our hospital, he bruised the left frontal area of his head. Magnetic resonance imaging showed homogeneously enhanced tumors with contrast media in the subcutaneous tissue corresponding to the head impact area and the cerebral parenchyma, but no obvious abnormal findings in the skull. A biopsy with craniotomy was performed under general anesthesia. The pathological diagnosis was diffuse large B-cell lymphoma. On histological examination, tumor cells grew aggressively under the skin. Tumor cells invaded along the emissary vein into the external table without remarkable bone destruction and extended across the skull through the Haversian canals in the diploe. Tumor cells were found only at the perivascular areas in the dura mater and extended into the brain parenchyma. Considering the history of head trauma and the neuroimaging and histological findings, the PCVL in the present case arose primarily under the skin, passed though the skull and dura mater, and invaded along vessels and reached the brain.
ISSN:1662-6575
1662-6575
DOI:10.1159/000516272