Dietary exposure to bisphenol A affects memory function and neuroimmune biomarkers in allergic asthmatic mice

• Published in: Journal of applied toxicology 2021-10, Vol.41 (10), p.1527-1536
• Main Authors: Win‐Shwe, Tin‐Tin, Yanagisawa, Rie, Koike, Eiko, Takano, Hirohisa
• Format: Article
• Language: English
• Subjects: Adapters; Allergens; allergic asthma; Animals; Asthma; Asthma - immunology; Automation; Automotive engines; Benzhydryl Compounds - toxicity; Biomarkers; Biomarkers - blood; Bisphenol A; Brain; Calcium; Cellular telephones; Civil engineering; Diet; Dietary Exposure - adverse effects; Disease Models, Animal; Electric appliances; Electronic equipment; Endocrine Disruptors - toxicity; Epoxy resins; Exposure; Heme; Hippocampus; Household appliances; Hypersensitivity; Immune system; Immunological memory; Impairment; Inflammation; Male; Medical equipment; Memory Disorders - chemically induced; memory function; Mice; Mice, Inbred C3H; neuroimmune biomarkers; Neuroimmunomodulation - drug effects; Neuroinflammatory Diseases - chemically induced; Neuroinflammatory Diseases - immunology; Object recognition; Office automation; Ovalbumin; Oxygenase; Pattern recognition; Phenols - toxicity; Polycarbonate; Polymerase chain reaction; Prostaglandin endoperoxide synthase; Trachea
• ISSN: 0260-437X; 1099-1263
• DOI: 10.1002/jat.4143

Bisphenol A (BPA) is a raw material of polycarbonate and epoxy resin. It is used for various household electrical appliances, electronic equipment, office automation equipment, medical equipment, mobile phones, paints for automobiles, internal surface coating of cans, and adhesives for civil engineering and construction. BPA is a well‐known endocrine‐disrupting chemical, and it was reported that BPA has an adverse effect on the nervous and immune systems. However, BPA‐induced memory impairment and changes in neuroimmune biomarkers in the allergic asthmatic subject are not known yet. We aim to investigate the dietary exposure effect of BPA on brain function and biomarkers using allergic an asthmatic mouse model. Five‐week‐old male C3H/HeJSlc mice were fed two doses of BPA [0.901, 9.01 μg/kg/day] contained chow diet from 5 to 11 weeks old and ovalbumin (OVA) was given by intratracheal instillation every 2 weeks. Memory function was determined by a novel object recognition test. Genes related to memory and immune markers in the hippocampus were investigated with the real‐time polymerase chain reaction (RT‐PCR) method. In this study, impaired novel object recognition occurred in BPA‐exposed mice in the presence of an allergen. Moreover, upregulation of expression level of neuroimmune biomarkers such as N‐methyl‐D‐aspartate receptor, tumor necrosis factor‐α, ionized calcium‐binding adapter molecule‐1, cyclooxygenase‐2, and heme oxygenase‐1 in the hippocampus was observed in BPA‐exposed allergic asthmatic mice. These findings show that BPA exposure can induce neuroinflammation and which triggers impairment of memory function in mice with allergic asthma. Our study indicated that dietary exposure to BPA may affect higher brain functions by modulating neuroimmune biomarkers in allergic asthmatic subjects. Dietary BPA exposure affects neuroimmune biomarkers. Dietary BPA exposure impaired memory in allergic asthmatic mice. Neuroimmune activation was observed in BPA in the presence of allergen.