Radioiodinated Azilsartan as a New Highly Selective Radiotracer for Myocardial Perfusion Imaging

Azilsartan (AZ) was labeled with 131 I using Chloramine-T as oxidizing agent. Factors affecting the labeling efficiency were systematically studied, and optimum conditions were found: oxidizing agent amount 100 μg, substrate amount 100 μg, pH 6, reaction time 30 min, and ambient temperature. Biodist...

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Bibliographic Details
Published in:Radiochemistry (New York, N.Y.) N.Y.), 2021-08, Vol.63 (4), p.520-525
Main Authors: Sanad, M. H., Marzook, F. A., Rizvi, S. F. A., Farag, A. B., Fouzy, A. S. M.
Format: Article
Language:English
Subjects:
Ambient temperature
Chemistry
Chemistry and Materials Science
Chemistry/Food Science
Nuclear Chemistry
Oxidation
Oxidizing agents
Radioactive tracers
Reaction time
Substrates
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Summary:Azilsartan (AZ) was labeled with 131 I using Chloramine-T as oxidizing agent. Factors affecting the labeling efficiency were systematically studied, and optimum conditions were found: oxidizing agent amount 100 μg, substrate amount 100 μg, pH 6, reaction time 30 min, and ambient temperature. Biodistribution studies showed that [ 131 I]iodoAZ is concentrated in heart at 5 min post-injection to give high uptake of 29.0 ± 0.6% injected dose/g organ. Thus, iodoAZ shows promise as a radiotracer for heart imaging.
ISSN:1066-3622
1608-3288
DOI:10.1134/S1066362221040160