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Rh(iii)-Catalyzed one-pot three-component cyclization reaction: rapid selective synthesis of monohydroxy polycyclic BINOL derivatives

A Rh(iii)-catalyzed three-component C–H bond functionalization protocol has been successfully applied to access complex polycyclic BINOL derivatives in which the formation of intermediate amides occurred in situ from aldehydes and amines. The high efficiency strategy allows the rapid selective synth...

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Bibliographic Details
Published in:Organic chemistry frontiers an international journal of organic chemistry 2021-09, Vol.8 (18), p.4967-4973
Main Authors: Liu, Hao, Meng-Ling, Lin, Yin-Jun, Chen, Yin-Hui, Huang, Lin, Dong
Format: Article
Language:English
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Summary:A Rh(iii)-catalyzed three-component C–H bond functionalization protocol has been successfully applied to access complex polycyclic BINOL derivatives in which the formation of intermediate amides occurred in situ from aldehydes and amines. The high efficiency strategy allows the rapid selective synthesis of diverse BINOL compounds in a step-economical manner from three readily accessible starting materials in one-pot.
ISSN:2052-4110
2052-4110
DOI:10.1039/d1qo00779c