Preventive effect of Bacillus mojavensis levan against carbon tetrachloride and cisplatin toxicity: in vivo study

This study is the first to investigate the hepato- and nephron-preventive effect of levan from Bacillus mojavensis (BM-levan) against toxicity induced by carbon tetrachloride (CCl 4 ) and cisplatin. Thirty-six male albino rats weighing between 230 and 250 g were used for this experiment. The groups...

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Bibliographic Details
Published in:Environmental science and pollution research international 2021-09, Vol.28 (36), p.50117-50126
Main Authors: Haddar, Anissa, Feriani, Anouar, Hamed, Mariem, Sila, Assaad, Ellouz-Chaabouni, Semia
Format: Article
Language:English
Subjects:
Alanine
Alanine transaminase
Animal models
Animals
Antioxidants
Antioxidants - metabolism
Aquatic Pollution
Aspartate aminotransferase
Atmospheric Protection/Air Quality Control/Air Pollution
Bacillus
Bacillus mojavensis
Biocompatibility
Biomarkers
Biomedical materials
Body weight
Carbon
Carbon tetrachloride
Carbon Tetrachloride - toxicity
Catalase
Chemical and Drug Induced Liver Injury - metabolism
Chemotherapy
Cholesterol
Cisplatin
Cisplatin - toxicity
Creatinine
Earth and Environmental Science
Ecotoxicology
Environment
Environmental Chemistry
Environmental Health
Environmental science
Fructans - metabolism
Glutathione
Glutathione peroxidase
High density lipoprotein
Histology
In vivo methods and tests
Kidneys
Levan
Lipid Peroxidation
Lipids
Liver
Liver - metabolism
Low density lipoprotein
Male
Oxidative Stress
Peroxidase
Peroxidation
Plant Extracts - metabolism
Rats
Research Article
Scavenging
Superoxide dismutase
Superoxide Dismutase - metabolism
Supplements
Toxicity
Triglycerides
Urea
Uric acid
Waste Water Technology
Water Management
Water Pollution Control
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Summary:This study is the first to investigate the hepato- and nephron-preventive effect of levan from Bacillus mojavensis (BM-levan) against toxicity induced by carbon tetrachloride (CCl 4 ) and cisplatin. Thirty-six male albino rats weighing between 230 and 250 g were used for this experiment. The groups received multiples doses of BM-levan and were compared to the untreated group. The in vitro and in vivo biological potentials of BM-levan were evaluated by measuring its antioxidant capacity as well as its hepato- and nephron-protective activities in rat models. The investigations highlighted a significant in vitro antioxidant activity indicated by the radical-scavenging capacity, the reducing power, and the total antioxidant activity measurement. In addition, results demonstrate that BM-levan supplementation during 8 weeks (100 mg/kg body weight) significantly ( p 
ISSN:0944-1344
1614-7499
DOI:10.1007/s11356-021-14147-3