Thin films of cross-linked polylactic acid as tailored platforms for controlled drug release

• Published in: Surface & coatings technology 2021-09, Vol.421, p.127402, Article 127402
• Main Authors: Krtouš, Zdeněk, Kousal, Jaroslav, Sedlaříková, Jana, Kolářová Rašková, Zuzana, Kučerová, Liliana, Krakovský, Ivan, Kučera, Jaromír, Ali-Ogly, Suren, Pleskunov, Pavel, Choukourov, Andrei
• Format: Article
• Language: English
• Subjects: Antiinfectives and antibacterials; Biocompatibility; Biodegradability; Buckling; Chemical composition; Controlled drug release; Controlled release; Crosslinking; Discharge; Dissolution; Kinetics; Mass distribution; Nisin; Oligomers; Plasma polymerization; Plasma-assisted vapour thermal deposition; Polyesters; Polylactic acid; Polymer films; Polymers; Power management; Thin films; Time; Topology; Viscoelasticity; Wound healing
• ISSN: 0257-8972; 1879-3347
• DOI: 10.1016/j.surfcoat.2021.127402

Drug-loaded polymers are desirable for the controlled administration of bioactive molecules to biological media because polymer viscoelasticity can be translated into benefits of tissue-contacting materials. Here, we report on plasma-assisted deposition of polyester thin films performed via thermal evaporation of polylactic acid (PLA). The films can be produced with the chemical composition and polymer topology precisely tuned by the discharge power. At low power, weakly cross-linked films are produced with the chemical motif resembling that of PLA, the molar mass distribution peaking at ~350 g × mol−1 and skewing to larger species. At high power, highly cross-linked films are produced with a worse resemblance to PLA. The films swell and dissolve in water, releasing oligomers with the dissolution kinetics spanning over a broad time scale of 10−1–104 s. The released oligomers undergo hydrolysis at the time scale of days and with the final product of lactic acid, meeting the biocompatibility demands. When dissolving, the films expose micrometre-sized pores or buckling instabilities, depending on the discharge power. The phenomenon can be used for controlled release of nisin, an antibacterial peptide so that an hour-delayed release is achieved via the pore-mediated diffusion, whereas a minute-delayed release is achieved through the buckling. Nisin-loaded polyester plasma polymer films are effective against Micrococcus luteus, the bactericidal activity correlating with the drug release kinetics. Hence, the film design holds promise for developing advanced wound dressing materials and other tissue-contacting devices with tunable therapeutic effect. [Display omitted] •Thin films of plasma polymers resembling classical polylactic acid were prepared.•The timescale of dissolution can be tuned within several orders of magnitude.•Two different mechanisms of degradation were observed.•Control of kinetics of release of nisin from minutes to days was demonstrated.